Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients.
نویسندگان
چکیده
In a randomized, double-blind trial, gamma radiation-sterilized, chlorhexidine-coated triple-lumen catheters were compared with uncoated control catheters for their ability to prevent catheter infection in 254 intensive care unit patients. The chlorhexidine coating was not efficacious, and a rabbit model demonstrated that reduction of chlorhexidine activity by gamma radiation sterilization was the likely explanation for the failure.
منابع مشابه
Influence of triple-lumen central venous catheters coated with chlorhexidine and silver sulfadiazine on the incidence of catheter-related bacteremia.
OBJECTIVE To evaluate the efficacy of triple-lumen central venous catheters coated with a combination product of chlorhexidine and silver sulfadiazine (CSS) in reducing the incidence of local catheter infection and catheter-related bacteremia. DESIGN Randomized, controlled trial. SETTING The surgical intensive care units in a university hospital. PATIENTS All patients who needed central v...
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متن کاملCost effectiveness of antimicrobial catheters in the intensive care unit: addressing uncertainty in the decision
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متن کاملPrevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter. A randomized, controlled trial.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 40 9 شماره
صفحات -
تاریخ انتشار 1996